It was inevitable, then, that Christian thinkers would attempt to more thoroughly understand the nature of Christ, using Greek analytical methods. How is it, they asked, that God could be human? How could God so alter Himself as to have a human form and a human life? Furthermore, if He had died for humanity's sins, how precisely did this happen? Can God die at all and remain God?
These are just a few of the questions that vexed the earliest Christian theologians. (By the way, some of these questions are still being asked!)
For a long time, these questions were asked in a less-than-serious manner. Christianity did not have a doctrine, per se, so any such speculation made little difference. After a while, however, when the episcopal synods began — slowly and in piecemeal fashion — to hammer out a single doctrine, the answers to all of these speculations began to matter. Some were acceptable, others were not.
For quite some time, this idea was known as the Samosatene Doctrine, after its first major proponent (though it may actually have predated Paul of Samosata). It created consternation, once word of it was passed around. One of the building-blocks of Christianity (as many saw it) had been the divinity of Christ. For Christ's divinity to come under attack, was a threat to the very foundations of the faith; that is came from inside the nascent Church, only made matters worse.
Still, it was a sensible answer to the many questions posed above, and was seen as a very logical conclusion, even by those who opposed it. Paul of Samosata was popular at first, but eventually, was driven from office. Without his episcopal pulpit from which to explain it, Paul and his doctrine faded from view.
The differences between the two sides grew ever more severe. The Samosatenes were convinced that the Alexandrians (that is, the Christian followers of Patriarch Alexander) were blaspheming, by elevating Christ to Godhood, when He was not divine. The Alexandrians were convinced the Samosatenes were blaspheming, by denying the divinity of Christ. Eventually, the conflict elevated to fisticuffs.
At this point, having been denounced, and with Alexandrian Christians almost at war with one another. Arius was no longer safe in Alexandria. He fled to the Patriarch of Jerusalem, with whom he had had a correspondence, and who supported him. Arius managed to convert many in Palestine and Syria. He was already elderly, by this time, but hale enough to traverse the Levant in favor of his teachings.
The majority of bishops at Nicaea decided to condemn the Samosatene Doctrine. They also condemned and excommunicated Arius. They did not, as is commonly assumed, adopt the "Trinity" at that time. The doctrine of the Trinity was developed over the next couple of decades, begun by Athanasius but ratified at the end of the 4th century in the Councils of Chalcedon and Constantinople. (The creed which came of these Councils is known as the Nicene Creed, however, this is a misnomer, as the Council of Nicaea adopted no creed whatsoever.)
Constantine had been furious over the results of the Council he'd requested. His goal had been to unify, not divide, Christianity. Instead, three Christianities emerged: "Orthodox," Arian, and Gnostic. Thus, when Arius showed up looking for asylum, the Emperor was only too happy to oblige; he could think of no better way to display his chagrin over the proceedings at Nicaea.
Arius died a couple of years later, but others picked up the banner of the Samosatene Doctrine (which became known as Arianism, after the presbyter's death). Arianism found something of a second home in the western part of the Roman Empire in its waning days. Partly, this is because Christianity was less sophisticated, there, and the notion of orthodoxy wasn't strictly enforced (since there were fewer people who understood doctrine well enough to tell the difference between orthodoxy and heresy!). Also, Arianism seems to have coincided more neatly with the "mystery religions" that were practiced in the west.
Despite this, small pockets of Arianism remained in the east. Over time, they blended into Monophysitism, another later heretical movement, which the Byzantine Emperors finally stamped out.
Since then, some Protestant Christian denominations have asserted the humanity of Christ over His divinity. So, while Arianism was dead for most of the Middle Ages, it has re-emerged. While still not a mainstream notion, many current Christians owe their views of Christ's nature to Paul of Samosata and Arius of Alexandria.
Arianism is often mistaken for a form of Gnosticism; but at no time did Paul of Samosata, Arius of Alexandria, or any of their successors teach a secret, mystical doctrine of the Gnostic style. Arianism was a form of Literal Christianity (as opposed to Gnostic). About the only thing the Arians had in common with Gnostics was their inclusion of Docetism in their doctrines. Otherwise, they were completely different, and in fact, Arians had a hand in suppressing Gnosticism — in spite of the fact that they, themselves, were under attack!
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